SS-31 (Elamipretide)

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SS-31 (Elamipretide) IV Infusion Details

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Function: Protects and repairs mitochondria, enhancing cellular energy production and reducing oxidative stress.

SS-31, also known as Elamipretide, is a peptide designed to protect and repair mitochondria, improve cellular function, and reduce oxidative stress. This peptide offers significant potential for enhancing cellular energy production, protecting against mitochondrial dysfunction, and supporting overall cellular health.

Uses:

Mitochondrial Diseases: Investigated for treating conditions caused by mitochondrial dysfunction, such as mitochondrial myopathy, heart failure, and neurodegenerative diseases.
Cardioprotection: Studied for its protective effects on the heart, particularly in ischemia-reperfusion injury.
Neuroprotection: Explored for its potential to protect neurons from oxidative stress and enhance cognitive function.

How P21 Functions: SS-31 selectively targets the inner mitochondrial membrane, where it binds to cardiolipin, a lipid unique to this membrane. By stabilizing cardiolipin, SS-31 helps maintain mitochondrial structure and function, reducing the production of reactive oxygen species (ROS) and protecting against oxidative damage. This action enhances ATP production, improving cellular energy status and protecting cells from stress and injury. In the context of neuroprotection, SS-31 supports neuronal health by mitigating oxidative stress and maintaining mitochondrial integrity, which is crucial for optimal brain function.

Peptide

SS-31 is a synthetic tetrapeptide with mitochondrial protective properties.

Physiological Roles

Protects mitochondria and enhances cellular energy production.

Research and Applications

Studied for mitochondrial diseases, cardioprotection, neuroprotection, and cognitive enhancement.

Clinical Significance

SS-31 is a promising therapeutic candidate for conditions involving mitochondrial dysfunction. It offers potential benefits in energy production and protection against cellular stress. Its role in enhancing mitochondrial function and protecting neurons makes it a valuable tool for improving cognitive health and mitigating the effects of neurodegenerative diseases.

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