SAMe is a naturally occurring metabolite found in the human body as well as in plant and animal foods. It is the most active of all methyl donors and has been compared to ATP in its importance for the body. SAMe is naturally synthesized in humans from the amino acid methionine in the presence of the cofactors B12 and folate.
Designs for Health’s SAMe capsules provide 200 mg of stabilized SAMe along with vitamins B6, B12, and folate as 5-MTHF in order to provide cofactors for the natural conversions of SAMe to L-homocysteine and then safely to L-cysteine.
Previously, SAMe was not viable in an encapsulated form due to its sensitivity to degradation from air and moisture. However, a unique technology with a patented stabilized powder facilitates the production of a capsule form of SAMe which prevents its breakdown by stomach acidity and allows for intact absorption in the small intestine. This technology also makes possible the inclusion of the B vitamin cofactors within the capsules.
SAMe is involved in the synthesis of neurotransmitters, the hormone melatonin, phospholipids, and polyamines, which control cellular growth. It is also the source of methyl groups inside the nucleus for DNA methylation, which controls gene expression and masking of genetic damage.